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Thursday, April 08, 2010

INOSITOL FOODS PREVENT CANCER?

Inositol is emerging as an anti cancer supplement with its multiple properties of inhibiting the cancer by making the cancer cells behave and grow more like normal cells. The anti-oxidant property of Inositol also making it as favorite among cancer preventive foods. May be later we can hear another proverb like this, ‘Eat one gram of Inositol  a day keep the doctor away’. Inositol or its phosphates and associated lipids are found in many foods. Let’s check about Inositol and its benefits in a little more detail.

What is Inositol ?

  INOSITOL

Inositol or cyclohexane-1,2,3,4,5,6-hexol is widely occurring, natural carbohydrate, but not classified as a classical sugar. It is almost tasteless, with a small amount of sweetness. The most prominent form of Inositol is cis-1,2,3,5-trans-4,6-cyclohexanehexol, or myo-inositol. Myo-Inositol was classified as a member of the vitamin B complex

Which foods are good source of Inositol ?

Whole grain cereals, such as rice, oats, wheat and corn, as well as legumes, which contain a natural anticancer agent known as IP-6 (inositol hexaphosphate). IP-6 combined with inositol helps  to prevent the growth of new tumors and shrink existing tumors.

It is present in cereals with high bran content, nuts, cantaloupe melons and oranges.

What are the possible benefits of Inositol supplement foods

Inositol and lung cancer

– Researches are going on in several universities about the potential chemo preventive effect of inositol. The potential chemo preventive effect of myo-inositol was estimated by repeat autofluorescence, bronchoscopy and biopsy. The maximum tolerated dose was found to be 18 grams per day. The side effects were negligible.

The anti-oxidant property of Inositol is very helpful in preventing cancer. Antioxidant property of inositol could be the result of its' quenching action on reactive oxygen, intermediates and conjugate-formation with compounds like arachidonic acid and the antiglycating property due to scavenging of glucose.

Inositol and  Central Nervous System

- Inositol is a simple polyol precursor in a second messenger system important in the brain. Inositol is helpful in reducing anxiety, Obsessive Compulsive Disorders and Panic disorders

Inositol and Blood Pressure

- Several studies show that  significant reduction in systolic and diastolic blood pressures by an average of 10 mm Hg was observed after taking 18 g/d of myo-inositol for a month or more.

Inositol and polycystic ovary syndrome

– Inositol have proven clinical evidences in improving ovarian function in women with oligomenorrhea and polycystic ovaries.

Inositol and impotence

- Myoinositol and folic acid combination helps in preventing and treating erectile dysfunction in diabetic men, as  a result of its acute antioxidant properties, and nitric oxide protective beneficial effects.

References:

1. Cancer Epidemiol Biomarkers Prev. 2006 Aug. Lam S, McWilliams A, LeRiche J, MacAulay C, Wattenberg L, Szabo E.
Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada.

2. Eur Rev Med Pharmacol Sci. 2003 Nov-Dec;7(6):151-9.

3. Eur Neuropsychopharmacol. 1997 May;7(2):147-55. Levine J. Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.

4. Eur Rev Med Pharmacol Sci. 2006 Sep-Oct. Agostini R, Rossi F, Pajalich R. First Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy.

5. http://jn.nutrition.org/cgi/content/full/133/11/3778S

6. http://www.ncbi.nlm.nih.gov/pubmed/10549173

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